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Sequestosome 1/p62-related pathways as therapeutic targets in hepatocellular carcinoma

15 Apr 2019

Abstract excerpt

INTRODUCTION: Protein sequestosome 1/p62 (p62) plays a crucial role in vital complex and interacting signaling pathways in normal and neoplastic cells. P62 is involved in autophagy, defense against oxidative stress via activation of the Keap1/Nrf2 system, in protein aggregation and sequestration, and in apoptosis. Autophagy contributes to cell survival and proliferation by eliminating damaged organelles,...

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PMID: 30987486
DOI: 10.1080/14728222.2019.1601703

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