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Article

p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2.

Molecular and cellular biology - 15 Nov 2018

Cloer E W, Siesser P F, Cousins E M, Goldfarb D, Mowrey D D, Harrison J S, Weir S J, Dokholyan N V, Major M B

Abstract excerpt

Cancer-derived loss-of-function mutations in the KEAP1 tumor suppressor gene stabilize the NRF2 transcription factor, resulting in a prosurvival gene expression program that alters cellular metabolism and neutralizes oxidative stress. In a recent genotype-phenotype study, we classified 40% of KEAP1 mutations as ANCHOR mutants. By immunoprecipitation, these mutants bind more NRF2 than wild-type KEAP1 and...

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Source

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Identifiers

PMID: 30126895
DOI: 10.1128/MCB.00644-17
PMCID: PMC6206457

Genes

KEAP1
SQSTM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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