Article

Antigenic landscape of a highly mutated SARS-CoV-2 Spike in ongoing viral evolution

2026-02-27

Abstract excerpt

The ongoing emergence of SARS-CoV-2 variants in an increasingly immune-experienced population is largely enabled by the plasticity of the Spike protein, which lies at the frontline of host immune pressure. Here, we investigated how extensive remodeling of the N-terminal domain (NTD) in Spike influences its antigenic properties. Using BA.2.87.1, a variant heavily mutated in this domain, we found that even large del...

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Literature Corpus work: 2426f832-a671-512a-8b2b-967ddabf0346
DOI: 10.64898/2026.02.27.708159

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