Article

Sin3a Associated Protein 130kDa, sap130, plays an evolutionary conserved role in zebrafish heart development

2023-03-31

Abstract excerpt

Hypoplastic left heart syndrome (HLHS) is a congenital heart disease where the left ventricle is reduced in size. A forward genetic screen in mice identified SIN3A associated protein 130kDa ( Sap130 ), a protein in the chromatin modifying SIN3A/HDAC1 complex, as a gene contributing to the digenic etiology of HLHS. Here, we report the role of zebrafish sap130 genes in heart development. Loss of sap130a, one of t...

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Identifiers and source

Literature Corpus work: b6ab6009-2b06-5b68-9165-6433a764670b
DOI: 10.1101/2023.03.30.534737

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