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Adult Human Glioblastomas Harbor Radial Glia-like Cells

30 Jan 2020

Abstract excerpt

Radial glia (RG) cells are the first neural stem cells to appear during embryonic development. Adult human glioblastomas harbor a subpopulation of RG-like cells with typical RG morphology and markers. The cells exhibit the classic and unique mitotic behavior of normal RG in a cell-autonomous manner. Single-cell RNA sequencing analyses of glioblastoma cells reveal transcriptionally dynamic clusters of RG-like...

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PMID: 32004492
DOI: 10.1016/j.stemcr.2020.01.007

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