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Article

Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma.

The Journal of investigative dermatology - 1 Apr 2016

George Jasmine, Nihal Minakshi, Singh Chandra K, Zhong Weixiong, Liu Xiaoqi, Ahmad Nihal

Abstract excerpt

Melanoma, the most aggressive form of skin cancer, is often fatal if not treated early. Therefore, novel target-based strategies are required to combat this neoplasm. The objective of this study was to determine the role and functional significance of the mitochondrial sirtuin 3 (SIRT3) in melanoma. We found that compared with normal primary and immortalized human melanocytes, SIRT3 is significantly overexpressed...

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Source

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Identifiers

PMID: 26743598
DOI: 10.1016/j.jid.2015.12.026
PMCID: PMC4808399

Genes

SIRT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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