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Article

SIRT6 histone deacetylase functions as a potential oncogene in human melanoma

9 Oct 2017

Abstract excerpt

Melanoma is an aggressive skin cancer that can rapidly metastasize to become fatal, if not diagnosed early. Despite recent therapeutic advances, management of melanoma remains difficult. Therefore, novel molecular targets and strategies are required to manage this neoplasm. This study was undertaken to determine the role of the sirtuin SIRT6 in melanoma. Employing a panel of human melanoma cells and normal human...

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PMID: 29234488
DOI: 10.18632/genesandcancer.153

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