Article

Loss of neurofibromin alters adult metabolism via effects during a developmental critical period

2026-07-31

Abstract excerpt

Metabolic alterations commonly accompany neurodevelopmental disorders and may contribute to their pathophysiology. Neurofibromatosis type 1 (OMIM 162200) is a genetic disorder that results from mutations in the NF1 gene and its encoded neurofibromin protein (Nf1). The disorder is multisystemic, affecting multiple aspects of development, physiology, and brain function. In addition, recent evidence suggests that Nf1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2b5ae45a-6c1c-543f-97a9-8a6c5be5e04a
DOI: 10.64898/2026.07.29.741559

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of neurofibromin alters adult metabolism via effects during a developmental critical periodDOI 10.64898/2026.07.29.741559Read

Neurofibromin regulates metabolic rate via neuronal mechanisms in <i>Drosophila</i>Semantic proximity Read

Effects of <i>Nf1</i> on sleep behavior are mediated through starvation caused by deficits in SARM1 dependent NAD+ metabolismSemantic proximity Read

Cell autonomous requirement of Neurofibromin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasisSemantic proximity Read

Impaired energy metabolism in a Drosophila model of mitochondrial aconitase deficiency.Semantic proximity Read

Neurofibromin 1 mediates sleep depth in <i>Drosophila</i>Semantic proximity Read

Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.Semantic proximity Read

Neurofibromin is essential to maintain metabolic function and sustain life in the adult mouseSemantic proximity Read

Developmental mitochondrial Complex I activity determines lifespanSemantic proximity Read

Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases.Semantic proximity Read

Yeast NDI1 expression prevents the unfolded protein response and reconfigures metabolism to restore neuronal function in mitochondrial complex I deficiencySemantic proximity Read

Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomicsSemantic proximity Read

Metabolic and behavioral effects of neurofibromin result from differential recruitment of MAPK and mTOR signaling.Semantic proximity Read