Article

Detection of reproducible liver cancer specific ligand-receptor signaling in blood

2023-09-25

Abstract excerpt

Cell-cell communication mediated by ligand-receptor interactions (LRI) is critical to coordinating diverse biological processes in homeostasis and disease. Lately, our understanding of these processes has greatly expanded through the inference of cellular communication, utilizing RNA extracted from bulk tissue or individual cells. Considering the challenge of obtaining tissue biopsies for these approaches, we cons...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 23b6b25d-f4ce-5e36-aff1-d15f85322c94
DOI: 10.1101/2023.09.25.559274

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Detection of reproducible liver cancer specific ligand-receptor signaling in bloodDOI 10.1101/2023.09.25.559274Read

A Single Cell Gene Expression Atlas of 28 Human LiversSemantic proximity Read

Resolving the fibrotic niche of human liver cirrhosis using single-cell transcriptomicsSemantic proximity Read

Transcriptional Profiling of Commonly Used Liver Cancer Cell Lines Reveals Disease-Specific Modeling Potential and Authentication ConcernsSemantic proximity Read

Single-cell and bulk RNA sequencing reveal ligands and receptors associated with worse overall survival in serous ovarian cancerSemantic proximity Read

Unveiling the pathogenesis of non-alcoholic fatty liver disease by decoding biomarkers through integrated single-cell and single-nucleus profilesSemantic proximity Read

talklr uncovers ligand-receptor mediated intercellular crosstalkSemantic proximity Read

Spatial single-cell interactome and niche-specific molecular signatures in alcohol-related liver diseaseSemantic proximity Read

Single‐cell RNA sequencing reveals the heterogeneity and intercellular communication of hepatic stellate cells and macrophages during liver fibrosisSemantic proximity Read

Inferring ligand-receptor cellular networks from bulk and spatial transcriptomic datasets with BulkSignalRSemantic proximity Read

An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinomaSemantic proximity Read

Lignature: A Comprehensive Database of Ligand Signatures to Predict Cell-Cell CommunicationSemantic proximity Read

An investigation of plasma cell-free RNA for the detection of colorectal cancer: From transcriptome marker selection to targeted validationSemantic proximity Read