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Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion

2023-02-07

Abstract excerpt

Determining how high body-mass index (BMI) at different time points influences the risk of developing type two diabetes (T2D), and affects insulin secretion and insulin sensitivity, is critical. By estimating childhood BMI in 441,761 individuals in the UK Biobank, we identified which genetic variants had larger effects on adulthood BMI than on childhood BMI, and vice-versa. All genome-wide significant genetic vari...

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Literature Corpus work
23b2e5c3-c36f-5754-a29f-f162ef905ae7
DOI
10.1101/2023.02.03.23285420
Open publication

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Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretionDOI 10.1101/2023.02.03.23285420
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