Circulating histones play a central role in COVID-19-associated coagulopathy and mortality

Abstract excerpt

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality COVID-19 has highlighted the lethal consequences of immunothrombosis; i.e., the cross-talk between coagulation, inflammation and the innate immune system. Patients with immunothrombosis have significant immune cell death, 1 which can release pro-coagulant 2 and cytotoxic 3 histones. Histones are small, positivelycharged...

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