Article

NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin de-condensation and nuclear envelope rupture

2019-06-06

Abstract excerpt

Neutrophil extracellular traps (NETs) are web-like DNA structures decorated with histones and cytotoxic proteins that are released by activated neutrophils to trap and neutralize pathogens during the innate immune response, but also form in and exacerbate sterile inflammation. Peptidylarginine deiminase 4 (PAD4) citrullinates histones and is required for NET formation (NETosis) in mouse neutrophils. While the in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a156c73f-5f56-5c09-91ab-5e29e5964eff
DOI: 10.1101/663427

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin de-condensation and nuclear envelope ruptureDOI 10.1101/663427Read

Recent progress in the mechanistic understanding of NET formation in neutrophilsSemantic proximity Read

Chromatin swelling drives neutrophil extracellular trap releaseSemantic proximity Read

Neutrophil Extracellular Traps: Double-Edged Swords of Innate ImmunitySemantic proximity Read

The responses of macrophages in interaction with neutrophils that undergo NETosis.Semantic proximity Read

Automated flow cytometric quantification of human neutrophil extracellular traps (NETs)Semantic proximity Read

NETs By-products and Extracellular DNA May Play a Key Role in COVID-19 Pathogenesis: Incidence on Patient Monitoring and TherapySemantic proximity Read

Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseationSemantic proximity Read

Moonlighting chromatin: when DNA escapes nuclear controlSemantic proximity Read

Netome: The Molecular Characterization of Neutrophil Extracellular Traps (NETs)Semantic proximity Read

Extracellular DNA NET-Works With Dire Consequences for HealthSemantic proximity Read

Nanoscale Mapping Reveals Periodic Organization of Neutrophil Extracellular Trap ProteinsSemantic proximity Read

NETosis and the Immune System in COVID-19: Mechanisms and Potential TreatmentsSemantic proximity Read