Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Trypanosoma brucei L11 Is Essential to Ribosome Biogenesis and Interacts with the Kinetoplastid-Specific Proteins P34 and P37

20 Aug 2019

Abstract excerpt

The human-pathogenic, eukaryotic parasite Trypanosoma brucei causes human and animal African trypanosomiases. Treatments for T. brucei suffer from numerous hurdles, including adverse side effects and developing resistance. Ribosome biogenesis is one critical process for T. brucei survival that could be targeted for new drug development. A critical checkpoint in ribosome biogenesis is formation of the 5S RNP,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA and protein synthesis mechanisms
Share to RNA modifications and cancer
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31434747
DOI: 10.1128/msphere.00475-19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Trypanosoma brucei L11 Is Essential to Ribosome Biogenesis and Interacts with the Kinetoplastid-Specific Proteins P34 and P37PMID 31434747Read ↗

Trypanosoma brucei Homologue of Regulator of Ribosome Synthesis 1 (Rrs1) Has Direct Interactions with Essential Trypanosome-Specific ProteinsSemantic proximity Read ↗

Characterization of a novel association between two trypanosome-specific proteins and 5S rRNA.Semantic proximity Read ↗

Non-canonical binding interactions of the RNA recognition motif (RRM) domains of P34 protein modulate binding within the 5S ribonucleoprotein particle (5S RNP).Semantic proximity Read ↗

Pentatricopeptide Repeat Proteins in Trypanosoma brucei Function in Mitochondrial RibosomesSemantic proximity Read ↗

Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomesSemantic proximity Read ↗

Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesisSemantic proximity Read ↗

Structural differences in translation initiation between pathogenic trypanosomatids and their mammalian hostsSemantic proximity Read ↗

Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian HostsSemantic proximity Read ↗

Identification and Validation of Toxoplasma gondii Mitoribosomal Large Subunit ComponentsSemantic proximity Read ↗

Key RNA-binding domains in the La protein establish tRNA modification levels in Trypanosoma bruceiSemantic proximity Read ↗

The Influence of Extra-Ribosomal Functions of Eukaryotic Ribosomal Proteins on Viral InfectionSemantic proximity Read ↗

An Update on Mitochondrial Ribosome Biology: The Plant Mitoribosome in the Spotlight.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.