Article

SARS-CoV-2 variant with higher affinity to ACE2 shows reduced sera neutralization susceptibility

2021-03-04

Abstract excerpt

<h4>Background</h4> Several new variants of SARS-CoV-2 have emerged since fall 2020 which have multiple mutations in the receptor binding domain (RBD) of the spike protein. <h4>Objective</h4> We aimed to assess how mutations in the SARS-CoV-2 RBD affect receptor affinity to angiotensin-converting enzyme 2 (ACE2) and neutralization by anti-RBD serum antibodies. <h4>Methods</h4> We produced a SARS-CoV-2 RBD mutan...

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Literature Corpus work: 2369341d-2ed3-5eac-8182-f3a505fd520f
DOI: 10.1101/2021.03.04.433887

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