Article

Altered affinity to ACE2 and reduced Fc functional antibodies to SARS-CoV-2 RBD variants

2022-07-10

Abstract excerpt

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants remains a formidable challenge to worldwide public health. The receptor binding domain (RBD) of the SARS-CoV-2 spike protein is a hotspot for mutations, reflecting its critical role at the ACE2 interface during viral entry. We comprehensively investigated the impact of RBD mutations, including 6 variants of concern (VOC) or inte...

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Literature Corpus work: ee44c3b0-9438-5b2b-a400-43f537f926cb
DOI: 10.1101/2022.07.07.22277364

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