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Molecular Insights into the Variability in Infection and Immune Evasion Capabilities of SARS-CoV-2 Variants: A Sequence and Structural Investigation of the RBD Domain.

Journal of chemical information and modeling - 22 Apr 2024

Wang Tian Hua, Shao Hai Ping, Zhao Bing Qiang, Zhai Hong Lin

Abstract excerpt

As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continuously emerge, an increasing number of mutations are accumulating in the Spike protein receptor-binding domain (RBD) region. Through sequence analysis of various Variants of Concern (VOC), we identified that they predominantly fall within the ο lineage although recent variants introduce any novel mutations in the RBD. Molecular...

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PMID: 38517012
DOI: 10.1021/acs.jcim.3c01730

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