Article
Molecular definition of severe acute respiratory syndrome coronavirus 2 receptor-binding domain mutations: Receptor affinity versus neutralization of receptor interaction.
Allergy - 1 Jan 2022
Vogel Monique, Augusto Gilles, Chang Xinyue, Liu Xuelan, Speiser Daniel, Mohsen Mona O, Bachmann Martin F
Abstract excerpt
BACKGROUND: Several new variants of SARS-CoV-2 have emerged since fall 2020 which have multiple mutations in the receptor-binding domain (RBD) of the spike protein. It is unclear which mutations affect receptor affinity versus immune recognition. METHODS: We produced wild type RBD, RBD with single mutations (E484K, K417N, or N501Y) or with all three mutations combined and tested their binding to ACE2 by biolayer...
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