Article
Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interaction.
BMC molecular and cell biology - 7 Jan 2022
Nelson-Sathi Shijulal, Umasankar P K, Sreekumar E, Nair R Radhakrishnan, Joseph Iype, Nori Sai Ravi Chandra, Philip Jamiema Sara, Prasad Roshny, Navyasree K V, Ramesh Shikha, Pillai Heera, Ghosh Sanu, Santosh Kumar T R, Pillai M Radhakrishna
Abstract excerpt
BACKGROUND: SARS-CoV-2, the causative agent of COVID-19 pandemic is a RNA virus prone to mutations. Formation of a stable binding interface between the Receptor Binding Domain (RBD) of SARS-CoV-2 Spike (S) protein and Angiotensin-Converting Enzyme 2 (ACE2) of host is pivotal for viral entry. RBD has been shown to mutate frequently during pandemic. Although, a few mutations in RBD exhibit enhanced transmission...
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