Article

Utilization of RT-PCR and Optical Genome Mapping in Acute Promyelocytic Leukemia with Cryptic PML::RARA Rearrangement: A Case Discussion and Systemic Literature Review

2024-11-11

Abstract excerpt

Acute promyelocytic leukemia (APL) is characterized by abnormal promyelocytes and t(15;17)(q24;q21) PML::RARA. Rarely, patients may have cryptic or variant rearrangements. All-trans retinoic acid (ATRA)/arsenic trioxide (ATO) is largely curative provided that the diagnosis is established early. We present a case in which the diagnostic work-up suggested a diagnosis of APL; however, FISH, using the PML/RARA dual fu...

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Literature Corpus work: 23657758-fd75-523c-9da1-81707d534a06
DOI: 10.20944/preprints202411.0719.v1

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