Detection of cytogenetically cryptic PML-RARA fusion in acute promyelocytic leukemia by rapid next generation sequencing

Abstract excerpt

Acute promyelocytic leukemia (APL) is a medical emergency that requires treatment to be initiated as soon as the disease is suspected in order to decrease the risk of early death, which is mostly caused by APL-associated coagulopathy. Currently, the diagnosis of APL relies on the detection of PML-RARA fusion by fluorescence in situ hybridization (FISH). However, rare cases are cytogenetically cryptic, negative by...

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