Article

Gene therapy targeting of AKAP6β-CaMKII signalosomes improves myocardial inflammation and heart failure in a swine model of cardiometabolic syndrome

2026-07-28

Abstract excerpt

<h4>Background</h4> Cardiometabolic heart failure with preserved ejection fraction (HFpEF) is associated with systemic and cardiac inflammation and diastolic dysfunction. A-kinase anchoring protein 6β (AKAP6β) is a scaffold protein located at the cardiomyocyte outer nuclear membrane that promotes pathological cardiac remodeling via the recruitment of multiple regulatory proteins including protein kinases. In mice...

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Literature Corpus work: 235e04d3-6f44-5159-a1d0-3d1badfefd17
DOI: 10.64898/2026.07.23.740435

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