Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments

Abstract excerpt

Cell-cell communication is essential for the regulated exchange of information between cells, coordinating critical cellular processes under physiological and pathological conditions. The extracellular matrix (ECM) is a complex three-dimensional (3D) intercellular macromolecular network that provides structural support to tissues, while actively modulating cellular functions and responses. ECM-mediated...