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Restricted Varicella-Zoster Virus Transcription in Human Trigeminal Ganglia Obtained Soon after Death

28 Jun 2012

Abstract excerpt

We analyzed the varicella-zoster virus (VZV) transcriptome in 43 latently infected human trigeminal ganglia (TG) with postmortem intervals (PMIs) ranging from 3.7 to 24 h. Multiplex reverse transcriptase PCR (RT-PCR) revealed no VZV transcripts with a PMI of <9 h. Real-time PCR indicated a significant increase (P = 0.02) in VZV ORF63 transcript levels but not the virus DNA burden with longer PMI. Overall, both...

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Herpesvirus Infections and Treatments
Poxvirus research and outbreaks
Virus-based gene therapy research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22740396
DOI: 10.1128/jvi.01331-12

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