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Encapsulating has-miR-29a into HuMSCs-derived Exosomes by a Nanoengineering Platform to Efficiently Alleviate Aβ1-42 Expression in APPswe-SH-SY5Y Cells

2022-12-28

Abstract excerpt

<h4>Background: </h4> Exosomes derived from human umbilical cord mesenchymal stem cells (HuMSCs) have been utilized as a potential therapeutic candidate to alleviate amyloid β-protein (Aβ) expression in APP/PS1 or 5XFAD transgenic mice due to their low immunogenicity and extensive sources. Accumulated evidence also suggests that encysting appropriate cargos into exosomes can more effectively reduce Aβ expression b...

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Literature Corpus work: 2333b5b1-c786-56ce-9e6e-8fa281d10504
DOI: 10.21203/rs.3.rs-2393359/v1

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