Article
Exosomes Secreted from HEK293-APP Swe/Ind Cells Impair the Hippocampal Neurogenesis.
Neurotoxicity research - 1 Jul 2017
Zheng Tingting, Pu Jiali, Chen Yanxing, Guo Zhangyu, Pan Hongyu, Zhang Ling, Zhang Heng, Sun Binggui, Zhang Baorong
Abstract excerpt
This study aimed to investigate the neurotoxicity of exosomes to cultured neuroblastoma and neurons in vitro and to mature and newborn neurons in the hippocampus in vivo. Recent in vitro and in vivo studies have shown that exosomes, small membranous vesicles secreted from many cell types, contain pathogenic proteins including full-length amyloid precursor protein (flAPP) and amyloid precursor protein (APP)...
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