Article
Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor.
Oncotarget - 6 Oct 2015
Schutsky Keith, Song D Gang, Lynn Rachel, Smith Jenessa B, Poussin Mathilde, Figini Mariangela, Zhao Yangbing, Powell Daniel J
Abstract excerpt
Using lentiviral technology, we recently demonstrated that incorporation of CD27 costimulation into CARs greatly improves antitumor activity and T cell persistence. Still, virus-mediated gene transfer is expensive, laborious and enables long-term persistence, creating therapies which cannot be easily discontinued if toxic. To address these concerns, we utilized a non-integrating RNA platform to engineer human T...
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