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Methylenetetrahydrofolate reductase deficiency alters cellular response after ischemic stroke in male mice

2019-11-29

Abstract excerpt

<h4>Objective</h4> Elevated homocysteine concentrations are a risk factor for stroke. A common genetic polymorphism in methylenetetrahydrofolate reductase ( MTHFR 677 C ➔ T) results in elevated levels of homocysteine. MTHFR plays a critical role in the synthesis of S -adenosylmethionine (SAM), a global methyl donor. Our previous work has demonstrated that Mthfr +/− mice, which model the MTHFR polymorphism in...

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Literature Corpus work
230b307e-65d2-560a-bd62-8cc2c3a48d6f
DOI
10.1101/857938
Open publication

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Methylenetetrahydrofolate reductase deficiency alters cellular response after ischemic stroke in male miceDOI 10.1101/857938
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