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The role of 5‐hydroxymethylcytosine in mitochondria after ischemic stroke

24 Jul 2018

Abstract excerpt

5-Hydroxymethylcytosine (5hmC) exists in DNA, RNA, and mitochondrial DNA (mtDNA) and plays an important role in many diseases. Specifically, 5hmC is involved in promoting gene expression, and this process is regulated by Tet enzymes. In this study, we identified that there is no difference in male mice and female mice at first; then we examined the levels of 5hmC in mtDNA and explored the relationship among 5hmC,...

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PMID: 30043506
DOI: 10.1002/jnr.24274

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