Article

Single Cell Spatial Transcriptomic Profiling Identifies a LINE1 Associated Disarrayed Immune Microenvironment in Hepatocellular Carcinoma

2023-12-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Hepatocellular carcinoma (HCC) is a lethal malignancy driven by complex interactions between cancer cells, immune cells, and additional stromal cells in the tumor microenvironment (TME). The LINE1 retrotransposon is a ubiquitous repeat RNA whose de-repression leads to significant cancer cell-intrinsic and TME changes that promote aggressive tumor characteristics. We leveraged s...

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Literature Corpus work: 22ee1bbd-a3f3-5b2b-a1e0-fe6d667c5504
DOI: 10.1101/2023.12.04.570014

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