Article

An RNAi screen to identify proteins required for cohesion rejuvenation during meiotic prophase in Drosophila oocytes

2023-12-15

Abstract excerpt

Accurate chromosome segregation during meiosis requires maintenance of sister chromatid cohesion, initially established during premeiotic S phase. In human oocytes, DNA replication and cohesion establishment occur decades before chromosome segregation and deterioration of meiotic cohesion is one factor that leads to increased segregation errors as women age. Our previous work led us to propose that a cohesion reju...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 22edd421-e012-54eb-9ce1-f4b924ac336a
DOI: 10.1101/2023.12.15.571853

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An RNAi screen to identify proteins required for cohesion rejuvenation during meiotic prophase in Drosophila oocytesDOI 10.1101/2023.12.15.571853Read

Rejuvenation of Meiotic Cohesion in Oocytes during Prophase I Is Required for Chiasma Maintenance and Accurate Chromosome SegregationSemantic proximity Read

Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errorsSemantic proximity Read

Preparation of Meiotic Chromosome Spreads from Mouse Oocytes for Assessment of Synapsis and RecombinationSemantic proximity Read

Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errorsSemantic proximity Read

Genetic control of meiosis surveillance mechanisms in mammalsSemantic proximity Read

Wapl releases Scc1-cohesin and regulates chromosome structure and segregation in mouse oocytesSemantic proximity Read

Live imaging RNAi screen reveals genes essential for meiosis in mammalian oocytes.Semantic proximity Read

Aging predisposes oocytes to meiotic nondisjunction when the cohesin subunit SMC1 is reduced.Semantic proximity Read

Recent Insights into Spindle Function in Mammalian Oocytes and Early Embryos1Semantic proximity Read

Mitotic chromosome alignment is required for proper nuclear envelope reassemblySemantic proximity Read

Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effectSemantic proximity Read

Age-Dependent Susceptibility of Chromosome Cohesion to Premature Separase Activation in Mouse Oocytes1Semantic proximity Read