Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation.

Molecular and cellular biology - 1 Jun 2002

Shivakumar Latha, Minna John, Sakamaki Toshiyuki, Pestell Richard, White Michael A

Abstract excerpt

The RASSF1A locus at 3p21.3 is epigenetically inactivated at high frequency in a variety of solid tumors. Expression of RASSF1A is sufficient to revert the tumorigenicity of human cancer cell lines. We show here that RASSF1A can induce cell cycle arrest by engaging the Rb family cell cycle checkpoint. RASSF1A inhibits accumulation of native cyclin D1, and the RASSF1A-induced cell cycle arrest can be relieved by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin D1
Share to G1 Phase
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins, Viral

Share to Protein Kinases

Share to ras Proteins

Share to Retinoblastoma Protein

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 12024041
DOI: 10.1128/MCB.22.12.4309-4318.2002
PMCID: PMC133879

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation.PMID 12024041Read ↗

RASSF1A Mediates p21Cip1/Waf1-Dependent Cell Cycle Arrest and Senescence through Modulation of the Raf-MEK-ERK Pathway and Inhibition of AktSemantic proximity Read ↗

The tumor suppressor RASSF1A in human carcinogenesis: an update.Semantic proximity Read ↗

Tumor susceptibility of Rassf1a knockout mice.Semantic proximity Read ↗

The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle progression <i>via</i> Retinoblastoma proteinSemantic proximity Read ↗

Cyclin D1 Is Transcriptionally Regulated by and Required for Transformation by Activated Signal Transducer and Activator of Transcription 3Semantic proximity Read ↗

Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression.Semantic proximity Read ↗

Cell cycle restriction is more important than apoptosis induction for RASSF1A protein tumor suppression.Semantic proximity Read ↗

RASSF4/AD037 Is a Potential Ras Effector/Tumor Suppressor of the RASSF FamilySemantic proximity Read ↗

A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stability.Semantic proximity Read ↗

The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.Semantic proximity Read ↗

p53 is a NF-Y- and p21-independent, Sp1-dependent repressor of cyclin B1 transcription.Semantic proximity Read ↗

Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.