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Article

Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells

17 Jun 2014

Abstract excerpt

The aim of this study was to investigate the role of the transcription factor, PAX6, in the development of retinoblastoma. The expression of endogenous PAX6 was knocked down using PAX6-specific lentivirus in two human retinoblastoma cell lines, SO-Rb50 and Y79. Cell proliferation functional assays and apoptotic assays were performed on the cells in which PAX6 was knocked down. The results revealed that PAX6...

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PMID: 24939714
DOI: 10.3892/ijmm.2014.1812

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