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Tryptophan Hydroxylase 1 Regulates High-Fat Diet-Induced Hepatic Indian Hedgehog Expression and Secretion in Mice

2026-03-25

Abstract excerpt

Activation of hedgehog (Hh) signaling in the liver is implicated in the progression of chronic liver diseases. Here, we show that increases in the expression of hepatic Indian hedgehog (Ihh), a hepatokine, its transcriptional regulator TAZ, periostin, and lipogenesis-related genes, as well as in plasma Ihh levels, precede weight gain in C57BL6 mice fed a high-fat diet compared with a chow diet. Intake of whey prot...

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Literature Corpus work: 22a7b56b-5d5f-514c-abd2-27b7d0c1e6fe
DOI: 10.20944/preprints202603.1968.v1

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