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Article

Efficacy of serotonin inhibition in mouse models of bone loss.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2011

Inose Hiroyuki, Zhou Bin, Yadav Vijay K, Guo X Edward, Karsenty Gerard, Ducy Patricia

Abstract excerpt

In a proof-of-concept study it was shown that decreasing synthesis of gut serotonin through a small molecule inhibitor of Tph1 could prevent and treat ovariectomy-induced osteoporosis in young mice and rats. In this study, we define the minimal efficacy of this Tph1 inhibitor, demonstrate that its activity is improved with the duration of treatment, and show that its anabolic effect persists on interruption....

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Source

Identifiers

PMID: 21608033
DOI: 10.1002/jbmr.439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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