Article
High-fat diet decreases tyrosine hydroxylase mRNA expression irrespective of obesity susceptibility in mice.
Brain research - 1 May 2009
Li Yulin, South Timothy, Han Mei, Chen Jiezhong, Wang Rui, Huang Xu-Feng
Abstract excerpt
Tyrosine hydroxylase is the rate-limiting enzyme in the synthesis of dopamine, a key neurotransmitter in the regulation of food intake. This study examined tyrosine hydroxylase mRNA expression in obese mice fed a high-fat diet. After 8 week feeding of high-fat diet mice were classified as diet-induced obese and obese-resistant according to body weight gain. They were then placed on different dietary interventions...
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