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“Single-Nuclei Analysis of the Unfolded Protein Response (SNUPR) reveals bortezomib resistance mechanisms in Multiple Myeloma”

2024-10-25

Abstract excerpt

<h4> Abstract </h4> The unfolded protein response (UPR) is a key stress resistance pathway that has become a key potential target for improving the efficacy of cancer chemotherapy. The UPR involves the activation of three ER-resident stress sensors: PERK, IRE-1 and ATF6 with different signalling outcomes leading to cell death or survival. These cell-fate decisions are difficult to predict and are the result of t...

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Literature Corpus work
229db818-5d9d-5621-b9da-012fff23f521
DOI
10.1101/2024.10.22.617161
Open publication

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“Single-Nuclei Analysis of the Unfolded Protein Response (SNUPR) reveals bortezomib resistance mechanisms in Multiple Myeloma”DOI 10.1101/2024.10.22.617161
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