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Article

Novelty-seeking behavior predicts vulnerability in a rodent model of depression.

Physiology & behavior - 3 May 2011

Stedenfeld Kristen A, Clinton Sarah M, Kerman Ilan A, Akil Huda, Watson Stanley J, Sved Alan F

Abstract excerpt

BACKGROUND: The onset of major depressive disorder is likely precipitated by a combination of heredity and life stress. The present study tested the hypothesis that rats selectively bred on a trait related to emotional reactivity would show differential susceptibility or resilience to the development of depression-like signs in response to chronic mild variable intermittent stress (CMS). METHODS: Male...

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Identifiers

PMID: 21303678
DOI: 10.1016/j.physbeh.2011.02.001
PMCID: PMC3925672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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