Article

Cellular Reprogramming by Notch Inhibition Regenerates Hair Cells and Afferent Neurons to Restore the Sense of Balance

2024-10-03

Abstract excerpt

Sensory hair cell loss in the vestibular organs of the inner ear causes balance disorders which are essentially irreversible due to the lack of hair cell regeneration. Here, we administered a γ-secretase inhibitor to an adult mouse model of vestibular hair cell loss. The treatment regenerated type I and type II hair cells and restored canal and otolith afferent innervation, resulting in a complete recovery of rota...

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Literature Corpus work: 2236ce51-0519-51d5-ba53-5a5ed7e44ff2
DOI: 10.1101/2024.10.02.616053

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