Article

Regulation of human cardiomyocyte excitation-contraction coupling by human cardiac fibroblasts

2020-01-01

Abstract excerpt

Physiologically, cardiomyocytes develop features that enable them to meet the contractile demands of the healthy, adult heart. Among the structural and functional changes during development, there is an engagement of the sarcoplasmic reticulum as the main regulator of cytoplasmic Ca2+ cycling. In human cardiac disease and in ageing, there is progressive disengagement of the sarcoplasmic reticulum, reducing the eff...

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Literature Corpus work: 2219d78c-0533-507c-b5db-56375d341726
DOI: 10.25560/79561

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