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Modeling hypertrophic cardiomyopathy with human cardiomyocytes derived from induced pluripotent stem cells

3 Jun 2022

Abstract excerpt

One of the obstacles in studying the pathogenesis of hypertrophic cardiomyopathy (HCM) is the poor availability of myocardial tissue samples at the early stages of disease development. This has been addressed by the advent of induced pluripotent stem cells (iPSCs), which allow us to differentiate patient-derived iPSCs into cardiomyocytes (iPSC-CMs) in vitro. In this review, we summarize different approaches to...

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PMID: 35659761
DOI: 10.1186/s13287-022-02905-0

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