Article

Drug-likeness evaluation and inhibitory mechanism of emodin derivative on cardiac fibrosis based on metastasis-asspcoated protein 3

2024-08-28

Abstract excerpt

<h4>Background: </h4> Previous research demonstrated that emodin inhibits cardiac fibrosis through metastasis-asspcoated protein 3 (MTA3), but its limited bioavailability hinders clinical application. <h4>Aim:</h4> To enhance emodin clinical potential, a new derivative, emodin succinyl ethyl ester, was synthesized by modifying the 3’-OH position. This study assessed its drug-likeness, anti-fibrotic properties, and...

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Literature Corpus work: 2210a7ef-1661-5c8f-a7e6-bbe516d976cf
DOI: 10.22541/au.172484858.81530221/v1

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