Article

Drug-likeness evaluation and inhibitory mechanism of emodin derivative on cardiac fibrosis based on MTA3 pathway

2024-07-02

Abstract excerpt

<title>Abstract</title> <p>Background In our previous research, we demonstrated that emodin inhibits cardiac fibrosis through MTA3. However, the limited bioavailability of emodin has hindered its clinical translation. Aim To safely and effectively apply the pharmacology of emodin to disease treatment, a new emodin derivative (emodin succinyl ethyl ester) was synthesized through structural modification at the 3'...

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Literature Corpus work: 169370ad-11f4-5306-b969-97105cf7fd8e
DOI: 10.21203/rs.3.rs-4658033/v1

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