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Drug-likeness evaluation and inhibitory mechanism of emodin derivative on cardiac fibrosis based 2 on metastasis-asspcoated protein

2024-08-31

Abstract excerpt

<h4>Background: </h4> Previous research demonstrated that emodin inhibits cardiac fibrosis through metastasisasspcoated protein 3 (MTA3), but its limited bioavailability hinders clinical application. <h4>Aim:</h4> To enhance emodin clinical potential, a new derivative, emodin succinyl ethyl ester, was synthesized by modifying the 3’-OH position. This study assessed its drug-likeness, anti-fibrotic properties, and...

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Literature Corpus work
1f4702b9-9b4b-5324-a207-50ea23bdf358
DOI
10.22541/au.172506411.14171261/v1
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Drug-likeness evaluation and inhibitory mechanism of emodin derivative on cardiac fibrosis based 2 on metastasis-asspcoated proteinDOI 10.22541/au.172506411.14171261/v1
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