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Piperacillin-Tazobactam Resistance Mechanisms in <i>Escherichia coli</i> and Identification of a CTX-M-255 β-Lactamase Selectively Conferring Resistance to Penicillin/β-Lactamase Inhibitor Combinations

2022-09-25

Abstract excerpt

Piperacillin/tazobactam (TZP) is a widely used penicillin/β-lactamase inhibitor combination with broad antimicrobial activity. Recently, Escherichia coli strains resistant to TZP but susceptible to third generation cephalosporins (TZP-R/3GC-S isolates) have been increasingly identified. Here, we investigated resistance mechanisms underlying the TZP-R/3GC-S phenotype in clinical E. coli isolates. A total of 29 T...

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Literature Corpus work
1bc88b57-745b-50bd-ae00-3d0ee9d75059
DOI
10.1101/2022.09.21.508968
Open publication

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Piperacillin-Tazobactam Resistance Mechanisms in <i>Escherichia coli</i> and Identification of a CTX-M-255 β-Lactamase Selectively Conferring Resistance to Penicillin/β-Lactamase Inhibitor CombinationsDOI 10.1101/2022.09.21.508968
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