Article
Genome-wide analysis in Escherichia coli unravels a high level of genetic homoplasy associated with cefotaxime resistance.
Microbial genomics - 1 Apr 2021
Coolen Jordy P M, den Drijver Evert P M, Verweij Jaco J, Schildkraut Jodie A, Neveling Kornelia, Melchers Willem J G, Kolwijck Eva, Wertheim Heiman F L, Kluytmans Jan A J W, Huynen Martijn A
Abstract excerpt
Cefotaxime (CTX) is a third-generation cephalosporin (3GC) commonly used to treat infections caused by Escherichia coli. Two genetic mechanisms have been associated with 3GC resistance in E. coli. The first is the conjugative transfer of a plasmid harbouring antibiotic-resistance genes. The second is the introduction of mutations in the promoter region of the ampC β-lactamase gene that cause chromosome-encoded...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Cefotaxime
- Drug Resistance, Bacterial
- Escherichia coli
- Escherichia coli Infections
- Genome, Bacterial
- Heteroplasmy
- Humans
- Microbial Sensitivity Tests
- Mutation
- Plasmids