Article

GCH1 genetic variation as a prognostic factor in Parkinson disease across populations

2026-08-14

Abstract excerpt

<h4>Background: </h4> Pathogenic variants in GCH1 have been associated with Parkinson's disease (PD), but the clinical phenotype and longitudinal disease course of GCH1-associated PD remain incompletely characterized. Objectives: To characterize the genetic spectrum, clinical phenotype, and longitudinal progression of GCH1-associated PD across multiple populations. <h4>Methods:</h4> Whole-genome sequencing (WGS) a...

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Literature Corpus work: 22093630-e6de-5f9f-94f8-f8ecf36794f7
DOI: 10.64898/2026.08.14.26359677

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