GCH1 variants contribute to the risk and earlier age-at-onset of Parkinson's disease: a two-cohort case-control study.

doi:10.1186/s40035-020-00212-3

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GCH1 variants contribute to the risk and earlier age-at-onset of Parkinson's disease: a two-cohort case-control study.

Translational neurodegeneration - 4 Aug 2020

Pan Hong-Xu, Zhao Yu-Wen, Mei Jun-Pu, Fang Zheng-Huan, Wang Yige, Zhou Xun, Zhou Yang-Jie, Zhang Rui, Zhang Kai-Lin, Jiang Li, Zeng Qian, He Yan, Wang Zheng, Liu Zhen-Hua, Xu Qian, Sun Qi-Ying, Yang Yang, Hu Ya-Cen, Chen Ya-Se, Du Juan, Lei Li-Fang, Zhang Hai-Nan, Wang Chun-Yu, Yan Xin-Xiang, Shen Lu, Jiang Hong, Tan Jie-Qiong, Li Jin-Chen, Tang Bei-Sha, Guo Ji-Feng

Abstract excerpt

BACKGROUND: Common and rare variants of guanosine triphosphate cyclohydrolase 1 (GCH1) gene may play important roles in Parkinson's disease (PD). However, there is a lack of comprehensive analysis of GCH1 genotypes, especially in non-coding regions. The aim of this study was to explore the genetic characteristics of GCH1, including rare and common variants in coding and non-coding regions, in a large population...

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Identifiers

PMID: 32746945
DOI: 10.1186/s40035-020-00212-3
PMCID: PMC7401216

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