Article

Rare but Relevant: Assessing Variants in Dystonia-linked Genes in Parkinson’s Disease

2025-07-11

Abstract excerpt

<h4>Background</h4> Dystonia and Parkinson’s disease (PD) show clinical and genetic overlap, but the relevance of dystonia gene variants in PD remains unclear. <h4>Objective</h4> To assess the frequency of dystonia-linked pathogenic variants in PD. <h4>Methods</h4> We screened sequencing data from 15,738 individuals (7,851 PD, 4,287 atypical parkinsonism, and 3,600 unaffected) from GP2 and AMP-PD for variants i...

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Literature Corpus work: 8c4c5644-4c8d-5030-9c77-11b64c02c3f7
DOI: 10.1101/2025.07.10.25330831

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