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Article

GSK-3Î², a pivotal kinase in Alzheimer disease

21 May 2014

Abstract excerpt

Alzheimer disease (AD) is the most common form of age-related dementia. The etiology of AD is considered to be multifactorial as only a negligible percentage of cases have a familial or genetic origin. Glycogen synthase kinase-3 (GSK-3) is regarded as a critical molecular link between the two histopathological hallmarks of the disease, namely senile plaques and neurofibrillary tangles. In this review, we...

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PMID: 24904272
DOI: 10.3389/fnmol.2014.00046

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