Article
Changes in prion replication environment cause prion strain mutation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2013
Gonzalez-Montalban Nuria, Lee Young Jin, Makarava Natallia, Savtchenko Regina, Baskakov Ilia V
Abstract excerpt
Interspecies prion transmission often leads to stable changes in physical and biological features of prion strains, a phenomenon referred to as a strain mutation. It remains unknown whether changes in the replication environment in the absence of changes in PrP primary structure can be a source of strain mutations. To approach this question, RNA content was altered in the course of amplification of hamster...
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